Nociception may arise from injury or the visceral disease, neural and somatic structures in body. Pain is described more broadly as non-malignant or malignant in origin. Pain may be response to injury or to any number of diseases that states provoke nociception. Many advances in electrophysiological studies and in imaging studies allow us to gain deeper insight into characteristics and the properties associated with phenomenon of chronic pain.

The chronic pain may also cause some other conditions or symptoms, such as anxiety and depression. It may contribute to decreased physical activities given apprehension of exacerbating pain.

The chronic pain impairs ability to direct attention, when compare to peer with a low intensity particularly or no chronic pain with high-intensive chronic pain that have reduced agility to perform some attention demanding tasks. Pain sensation appears to capture strongly attention of people with chronic pain.

The individuals with highest levels of pain showed disruption of memory traces and suggested that the pain diminishes working memory. In the chronic pain treatment, due to processes or being malignant 3 steps WHO Ladder Analgesic is used. It provide the guidelines for some stepping up amount of analgesia and then maintains general basic that is used in number of countries around the world for better management of chronic pain.