Its treatments includes removal of tumor surgically, radiation therapy, immunotherapy or chemo. The familial melanoma is heterogeneous genetically and loci for the familial melanoma that have been identified on chromosome arms. Multiple genetic events are related to pathogenesis of melanoma. Multiple tumor suppressor geneses encode a low molecular weight proteins inhibitor of the dependent protein that has been localized to p21 region of the human chromosome.

Numbers of rare mutation that often run in the families are mostly known to greatly increase susceptibililty to the melanoma.

A complete surgical excision with adequate margins for presence of detectable disease is along with short as well as long-term followup. It is a common pattern of the treatment failure in melanoma.

Attempts to improve the survival by surgically removing lymph nodes were associated with many complications; unfortunately no survival benefit is there overall. Techniques of sentinel lymph node have been developed to reduce the overall complications of the lymph node surgery while it is allowing assessment of involvements of nodes with tumor. Without prolonging survival and controversial biopsy, it is often performed, mucosal tumors, tumor of limbs and ocular melanoma. A fine needle aspiration may also be performed alternatively; it is often used to masses tests.